Infections disco-vertébrales bactériennes sans matériel : épidémiologie, physiopathologie et diagnostic Revue générale
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Keywords

Native vertebral osteomyelitis
Epidemiology
Blood cultures
Image-guided aspiration biopsy

Categories

How to Cite

Kaoual, S., Chaaba, Y., Ernandes, H., Benzarti, S., Jribi, R., Sallem, S., Bellaaj, A., Chatti, L., Kooli, I., Masmoudi, A., & Besbes, S. (2025). Infections disco-vertébrales bactériennes sans matériel : épidémiologie, physiopathologie et diagnostic Revue générale. Revue Tunisienne De BIOLOGIE CLINIQUE, 31(3). https://doi.org/10.71699/revtunbiolclin.v31i3.267

Abstract

Native vertebral osteomyelitis (NVO) refers to infection of the intervertebral disc and adjacent vertebral bodies, potentially extending to paravertebral soft tissues or the epidural space, primarily through hematogenous spread, though rarely through contiguous dissemination or following a non-instrumental intervertebral intervention. The leading etiologies of NVO are tuberculosis, pyogenic infections, and brucellosis. Diagnosis should be considered in patients presenting with febrile back pain, especially when accompanied by inflammatory biomarkers or clinical red flags and confirmed via spinal magnetic resonance imaging. Microbiological identification remains essential, utilizing blood cultures, serological testing for brucellosis, and evaluation for extra-spinal tuberculosis. In cases where the etiology remains uncertain,               Image-guided aspiration biopsy with microbiological and histological analysis of tissue samples is indicated. Molecular biology techniques have shown high sensitivity and are particularly useful in cases with prior antibiotic exposure or when standard etiological investigations are inconclusive. This review provides an up-to-date summary of the epidemiology, pathophysiology, and diagnostic approach for bacterial NVO.

https://doi.org/10.71699/revtunbiolclin.v31i3.267
PDF (Français (France))

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Copyright (c) 2025 Salma Kaoual, Yosr Chaaba, Helmi Ernandes, Sofien Benzarti, Rahma Jribi, Sahar Sallem, Ameni Bellaaj, Lamia Chatti, Ikbel Kooli, Afef Masmoudi, Sophia Besbes

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