Study of bronchial structural changes induced by sodium fluoride

Abstract

Asthma is a chronic inflammatory disease of the lung. Its morbidity and mortality are in progressive increase despite progress done on the management of this disease. New therapeutic tools should be established. It has been proved that sodium fluoride (NaF) had a bronchorelaxant action. Therefore, there are no structural studies proving this action. So, the purpose of this study is to illustrate structural bronchial modifications after the inhalation of NaF at 0,5 M in rats. Methods : Three groups of male Wistar rats with medium weight of 230 ± 30 g inhaled respectively acethylmetylcholine (ACMCH), NaF at 0,5 M and saline solution. Rats were anesthetized by Ketamine 150 mg/Kg. Bronchial structural changes were studied on rats after having been sacrificed. Results : NaF 0,5 M have led to structural changes on bronchi : modification of the thickness of the muscular layer and changes of peribronchial vessels. Compared to group of ACMCH, NaF 0,5 M led to a reduction of mucine on the bronchial lumen. Conclusion : NaF 0,5M, by its metabolic action, can be used as a treatment of the bronchial spasm.