The biotransformation of Tetrazolium into Formazan applied to the preselection of new drugs for anticancer purposes
No. 16 (2004), Original article
No. 16 (2004)

The biotransformation of Tetrazolium into Formazan applied to the preselection of new drugs for anticancer purposes

Original article
https://doi.org/10.71699/revtunbiolclin.vi16.209
Published 2004-10-30
  • Th TABKA
  • A. BEN SASSI
  • I. CHERAIEF
  • T. HOMRI
  • H. CHAABANI
  • B. BEN HASSINE
Th TABKA
A. BEN SASSI
I. CHERAIEF
T. HOMRI
H. CHAABANI
B. BEN HASSINE
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Keywords

Cytotoxicity
Leukemia L1210
Tetrazolium
Formazan
Trichloro-methyl ethanol

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How to Cite

TABKA, T., BEN SASSI, A., CHERAIEF, I., HOMRI, T., CHAABANI, H., & BEN HASSINE, B. (2004). The biotransformation of Tetrazolium into Formazan applied to the preselection of new drugs for anticancer purposes. Revue Tunisienne De BIOLOGIE CLINIQUE, (16). https://doi.org/10.71699/revtunbiolclin.vi16.209
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Abstract

The intracellular biotransformation of XTT into Formazan has been applied to assess the cytotoxic activity of anticancer drugs, mainly derivatives of trichloro-methyl-ethanol, on murine leukemia L1210 cells in vitro. The concentration that inhibits the growth of 50% of the cultured cells is determined for each product, and the cytotoxicity is compared to that of Cisplatin (CDDP). This colorimetric technique using a tetrazolium salt has its advantages but must be employed with certain precautions.

https://doi.org/10.71699/revtunbiolclin.vi16.209
PDF (Français (France))
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Copyright (c) 2004 Revue Tunisienne de BIOLOGIE CLINIQUE

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